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Organ perfusion

Increasing utilization of donated organs and improving transplantation outcomes

Machine perfusion, also called organ perfusion, is used to preserve donated organs outside of the body (ex vivo) by circulating the blood vessels of the organs with a solution and sometimes with the addition of oxygen. It can be used as an alternative to static cold storage while preserving and transporting organs, and to assess whether organs are suitable for transplantation.

Machine perfusion has been demonstrated to increase the utilization of donated organs, improve post-transplant outcomes and extend the time an organ can be kept viable outside the body.

Globally, around 150,000 transplants are performed every year, corresponding to only 10% of the need according to WHO.

What percentage of donated organs are utilized?

Global average 2015–2022

Lung 20%
Heart 30%
Kidney 70%
Liver 65%

Increasing utilization of donated organs


Extend the viability of organs compared to traditional static cold storage, by providing an oxygenated solution to the tissues.


Support improved transplant logistics, potentially transporting organs over longer distances, or shifting-time of surgery.


Assess organ function during warm perfusion to decide whether the organ can be accepted for transplantation.

Machine perfusion for all major organs

Comparing two methods

Static cold storage

Static cold storage

  • Reduces organ metabolism, decreasing the need for oxygen
  • Limits preservation time
  • Does not allow for assessment of organ suitability for transplantation
Xvivo Machine Perfusion

Machine perfusion

  • A continuous flow of a perfusion solution, delivering oxygen to the organ
  • Allows for extended preservation time
  • Allows for organ assessment to determine suitability for transplantation

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