Since its introduction, Liver Assist has emerged as the primary device utilized in the major European trials, with its application documented in over 85 peer-reviewed publications. The system provides clinicians a choice of perfusion protocols, whether it’s hypothermic (HOPE or DHOPE), normothermic, sub-normothermic, or a combination with Liver Assist. These complementary protocols all serve different purposes from improving patient outcomes to increasing organ utilization.
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Read more about the productHypothermic oxygenated machine perfusion, HOPE or DHOPE, is widely recognized for its ability to reduce the incidence and severity of ischemia-reperfusion injury (IRI). Liver Assist supports both DHOPE (perfusion of both the portal vein and the hepatic artery) and HOPE (single-sided perfusion of the portal vein only). Published in over 50 peer-reviewed scientific papers, the clinical benefits of hypothermic machine perfusion using Liver Assist is well documented.
One of the more sophisticated protocols that Liver Assist supports is sequential use of DHOPE and NMP. In a recent Cochrane Review[1] on Liver Machine perfusion, Compared to SCS, (D)HOPE was shown to improve liver graft survival, reduce the number of serious adverse events, and reduce damage to the bile ducts. While NMP did not appear to have the same benefits, it does allow for viability assessment of the donor liver prior to transplantation into recipient. Sequential DHOPE and NMP combines the benefits of both perfusion protocols, enabling the safe transplant of otherwise high-risk livers.
For instance, University Hospital Groningen, has established a framework based on clinical data to guide the precise application of different protocols: Schematic overview of liver perfusion protocols used at UMCG. Image adapted from van Leeuwen OB, Porte RJ. Ex situ machine preservation of donor livers for transplantation: HOPE for all?. Br J Surg. 2021;108(10):1139-1141. doi:10.1093/bjs/znab293