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Liver Assist™

Unlock the power of flexibility

XVIVO's Liver Assist™ provides clinicians with a choice of perfusion protocols, whether it’s hypothermic (HOPE or DHOPE), normothermic, sub-normothermic, or a combination. These complementary protocols all serve different purposes, from improving patient outcomes to increasing organ utilization.

Not available in all markets. Please contact XVIVO for more information regarding availability in your specific region.
CAUTION: This is an unapproved device limited by Federal (or United States) Law to non-clinical research use only and is not commercially available for sale within the United States.

Benefits of Liver Assist™

Liver Assist™ has, since its introduction, emerged as the primary device utilized in major European trials. The system has been documented in more than 100* peer-reviewed publications – and no fewer than five randomized control trials – over the last 25 years.

*incl. Publications on IFLT

IMPROVED OUTCOMES

64%

Reduced risk of developing NAS¹

REDUCED TREATMENT COSTS

-€25,832

Transplant-related costs per patient (DHOPE vs. SCS alone) ²

EXPANDED DONOR POOL

DBD, DCD & ECD

Made possible by optimization of liver grafts and viability assessment before implantation. ^{3, 4}

LIVER ASSIST™

25 years of setting new standards

For 25 years, Liver Assist™ has harnessed the power of flexibility  to raise standards in liver transplantation, giving clinicians more time and choices when making life-saving decisions.

Watch a presentation about Liver Assist™ Read our clinical scientific summaries

Liver Assist™ at a glance

Centrifugal pressure-controlled pumps provide an independent continuous flow on the portal vein side and a pulsatile pattern on the hepatic artery side, similar to the physiological arterial perfusion (60 bpm)
Flexible temperature-controlled perfusion 12-37°C
Supports up to 24 hours hypothermic perfusion and 6 hours normothermic perfusion
Hollow fiber membrane oxygenator provides a high oxygen tension and concentration throughout the perfusion, optimizing oxygen transport efficiency

Learn more about machine perfusion

Principles of operation

1. Liver reservoir: dedicated chamber giving access to the perfused liver while keeping it protected and humid

2. Pulsatile perfusion: mimicking physiological conditions, the hepatic artery is perfused with a pulsatile flow

3. Oxygenation: oxygen/gas exchange via a separate hollow fiber oxygenator

4. Monitoring & sampling: Integrated sensors monitor real time flow, pressure and temperature. Direct sampling options for analysis of perfusate

5. Continuous perfusion: mimicking physiological circumstances, the portal vein is perfused with a continuous flow

REFERENCES

Benefits of Liver Assist™

van Rijn R, et al. Hypothermic Machine Perfusion in Liver Transplantation – A Randomized Trial. N Engl J Med. 2021;384(15):1391-401
Endo C, et al. Cost-effectiveness of Dual Hypothermic Oxygenated Machine Perfusion Versus Static Cold Storage in DCD Liver Transplantation. Transplantation. 2024
van Leeuwen OB, et al. Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers. Am J Transplant. 2022;22(6):1658-70
Dutkowski P, et al. First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis. Ann Surg. 2015;262(5):764-70; discussion 70-1.