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Liver Assist

Liver Assist™

Unlock the power of flexibility

XVIVO - Liver assist
Unlock the power of flexibility

XVIVO's Liver Assist provides clinicians a choice of perfusion protocols, whether it’s hypothermic (HOPE or DHOPE), normothermic, sub-normothermic, or a combination.

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CAUTION: This is an unapproved device limited by Federal (or United States) Law to non-clinical research use only and is not commercially available for sale within the United States. Not available in all markets. Please contact XVIVO for more information regarding availability in your specific region.

Benefits of Liver Assist™

Protocol of choice

enabled by flexible temperature range of 12-37°C.

Extended time

to ease transplantation logistics*.

Improved outcomes

for decreased donor transplant recipients.

Viability assessment

enabled by perfusion at near physiological conditions.

*up to 24 hours cold perfusion or 6 hours warm perfusion

Liver Assist has, since its introduction, emerged as the primary device utilized in major European trials. The system has been documented in over 85 peer-reviewed publications. Liver Assist provides clinicians a choice of perfusion protocols, whether it’s hypothermic (HOPE or DHOPE), normothermic, sub-normothermic, or a combination. These complementary protocols all serve different purposes from improving patient outcomes to increasing organ utilization.

Liver Assist™ at a glance

Liver Assist™ at a glance

  • Centrifugal pressure-controlled pumps provide an independent continuous flow on the portal vein side and a continuous pulsatile pattern on the hepatic artery side, similar to the physiological arterial perfusion (60 bpm)
  • Flexible temperature-controlled perfusion 12-37°C
  • Enables viability assessment during NMP
  • Supports up to 24 hours hypothermic perfusion and 6 hours normothermic perfusion
  • Hollow fiber membrane oxygenator provides a high oxygen tension and concentration throughout the perfusion, optimizing oxygen transport efficiency
Learn more about machine perfusion

Principles of operation

1. Liver reservoir: dedicated chamber giving access to the perfused liver while keeping it protected and humid

2. Pulsatile perfusion: mimicking physiological circumstances, the hepatic artery is perfused with a pulsatile flow

3. Oxygenation: oxygen/gas exchange via a separate hollow fiber oxygenator

4. Monitoring & sampling: Integrated sensors monitor real time flows, pressures and temperatures. Direct sampling options for analysis of perfusate

5. Continuous perfusion: mimicking physiological circumstances, the portal vein is perfused with a continuous flow

 

Xvivo - Liver Assist principles operation

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