Preservation powered by the gold standard
Gold standard in lung preservation for more than 25 years
Used in more than 90,000 lung transplantations*
Used by over 90% of all lung transplantation clinics
*40,000 lung transplantations with PERFADEX® Plus and 50,000 with PERFADEX®
*Depends on the condition of the lung and the established routines at the hospital.
Pre-buffered and pre-supplemented with calcium ions and THAM.
No risk of mistakes when adding and mixing buffer and electrolyte.
Click port allows tubing to be connected spike-free with one simple click.
Watch Prof. Niels van der Kaaij explain how an additional retrograde flush with PERFADEX® Plus showed a positive effect on reducing PGD3 in a recent pilot study.
Dextran counteracts tissue edema
PERFADEX® Plus is a slightly hyper-oncotic solution containing dextran 40 which counteracts tissue edema.
Dextran protects the vasculature
The key component of PERFADEX® Plus is dextran 40. It coats the endothelium preventing activation of leukocytes and thrombocytes. The tissue is thereby protected against post-ischemic reperfusion injury.
Calcium is important to maintain endothelial and epithelial cell integrity and endothelial contractility. Loss of cellular integrity results in injured and leaking endothelium and epithelium which in turn leads to edema.
The main function of a lung is to release CO2 and take up O2, which is dependent on the thickness of the interstitium. A thick interstitium increases the distance and thereby the time it takes for the molecules to move between compartments.
To achieve a physiological pH, the solution is buffered with THAM, included during production to provide a safe and ready-to-use product.