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PERFADEX® Plus

Preservation powered by the gold standard

PERFADEX® Plus
Safe preservation of donor lungs

PERFADEX® Plus is a ready-to-use solution for lung preservation, indicated for the flushing, cold static storage and transportation of isolated lungs after removal from the donor.

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Disclaimer: Not available in all markets. Please contact XVIVO for more information regarding availability in your specific region.

The established method of lung preservation

YEARS
25

Gold standard in lung preservation for more than 25 years

TRANSPLANTATIONS
90,000

Used in more than 90,000 lung transplantations*

OF CLINICS
90%

Used by over 90% of all lung transplantation clinics

*40,000 lung transplantations with PERFADEX® Plus and 50,000 with PERFADEX®

Safe preservation of lungs

FOR AT LEAST 12H*
12h
At temperatures FROM 2 to 10°C*
2-10ºC

*Depends on the condition of the lung and the established routines at the hospital.

Ready-to-use solution - whenever you need it.

Ready

Pre-buffered and pre-supplemented with calcium ions and THAM.

Safe

No risk of mistakes when adding and mixing buffer and electrolyte.

Easy

Click port allows tubing to be connected spike-free with one simple click.

Do you flush your donor lungs enough?

Watch Prof. Niels van der Kaaij explain how an additional retrograde flush with PERFADEX® Plus showed a positive effect on reducing PGD3 in a recent pilot study.

Practical advantages of PERFADEX® Plus

Ready to use – minimal steps required

Ready to use – minimal steps required

  • Pre-buffered with THAM and pre-supplemented with calcium ions
  • Ready to use whenever you need it – no additives required
  • Reduces the number of steps needed before using the product
  • Cost-saving – no product is discarded if the lungs cannot be recovered
Safe to use – less risk of mistakes and contamination:

Safe to use – less risk of mistakes and contamination:

  • Pre-buffered and pre-supplemented eliminates the risk of mistakes when adding and mixing buffer and electrolyte
  • Free from PVC, latex and phthalates for patient safety
  • No adverse reactions reported using PERFADEX® Plus
Easy to use - trouble free connection and replacement:

Easy to use - trouble free connection and replacement:

  • Click port and XVIVO Click Adapter allow tubing to be connected spike-free with one simple click
  • The tubing can rotate on its own axis for improved flexibility
  • Reduces the steps required before use
  • Easily removed when changing to a new bag
  • No need for a filter

How does PERFADEX® Plus work?

Dextran counteracts tissue edema and protects the vasculature
How does PERFADEX® Plus work?

Dextran counteracts tissue edema and protects the vasculature

Dextran counteracts tissue edema
PERFADEX® Plus is a slightly hyper-oncotic solution containing dextran 40 which counteracts tissue edema.

Dextran protects the vasculature
The key component of PERFADEX® Plus is dextran 40. It coats the endothelium preventing activation of leukocytes and thrombocytes. The tissue is thereby protected against post-ischemic reperfusion injury.

Calcium maintains cell integrity
How does PERFADEX® Plus work?

Calcium maintains cell integrity

Calcium is important to maintain endothelial and epithelial cell integrity and endothelial contractility. Loss of cellular integrity results in injured and leaking endothelium and epithelium which in turn leads to edema.

Thickness of the interstitium
How does PERFADEX® Plus work?

Thickness of the interstitium

The main function of a lung is to release CO2 and take up O2, which is dependent on the thickness of the interstitium. A thick interstitium increases the distance and thereby the time it takes for the molecules to move between compartments.

Buffered with THAM
How does PERFADEX® Plus work?

Buffered with THAM

To achieve a physiological pH, the solution is buffered with THAM, included during production to provide a safe and ready-to-use product.

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