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PERFADEX® Plus

PERFADEX® Plus

Preservation powered by the gold standard

Xvivo - Perfadex Plus
Preservation powered by the gold standard

PERFADEX® Plus is an extracellular, low potassium, dextran-based electrolyte preservation solution indicated for the flushing, cold static storage and transportation of isolated lungs after removal from the donor in preparation for eventual transplantation into a recipient.

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Disclaimer: Not available in all markets. Please contact XVIVO for more information regarding availability in your specific region.

Ready-to-use solution for lung preservation

PERFADEX® Plus is pre-supplemented with calcium ions and THAM, and thus ready to use whenever you need it.

Gold standard in lung preservation for more than 25 years

Used in more than 75,000 lung transplantations*

Used by more than 90% of all lung transplantation clinics

*25,000 lung transplantations with PERFADEX® Plus and 50,000 with PERFADEX

Safe preservation of lungs up to 12 hours

Safe preservation of lungs up to 12 hours

PERFADEX Plus enables the safe preservation of donor lungs for up to 12 hours, depending on the quality of the donor lung being retrieved.

Ready to use

Pre-buffered and pre-supplemented with calcium ions and THAM.

Safe to use

No risk of mistakes when adding and mixing buffer and electrolyte.

Easy to use

Click port allows tubing to be connected spike-free with one simple click.

How does PERFADEX® Plus work?

Dextran counteracts tissue edema and protects the vasculature
How does PERFADEX® Plus work?

Dextran counteracts tissue edema and protects the vasculature

Dextran counteracts tissue edema
PERFADEX Plus is a slightly hyper-oncotic solution containing dextran 40 which counteracts tissue edema.

Dextran protects the vasculature
The key component of PERFADEX Plus is dextran 40. It coats the endothelium preventing activation of leukocytes and thrombocytes. The tissue is thereby protected against post-ischemic reperfusion injury.

Calcium maintains cell integrity
How does PERFADEX® Plus work?

Calcium maintains cell integrity

Calcium is important to maintain endothelial and epithelial cell integrity and endothelial contractility. Loss of cellular integrity results in injured and leaking endothelium and epithelium which in turn leads to edema.

Thickness of the interstitium
How does PERFADEX® Plus work?

Thickness of the interstitium

The main function of a lung is to release CO2 and take up O2, which is dependent on the thickness of the interstitium. A thick interstitium increases the distance and thereby the time it takes for the molecules to move between compartments.

Buffered with THAM
How does PERFADEX® Plus work?

Buffered with THAM

To achieve a physiological pH, the solution is buffered with THAM. Included during production to provide a safe and ready-to-use product.

Practical advantages of PERFADEX® Plus

Ready to use – minimum steps to be taken before use:

Ready to use – minimum steps to be taken before use:

  • Pre-buffered with THAM and pre-supplemented with calcium ions
  • Ready to use whenever you need it – no additives required
  • Reduces the number of steps needed before using the product
  • Cost-saving – no product is discarded if the lungs cannot be recovered

Safe to use – less risk of mistakes and contamination:

  • Pre-buffered and pre-supplemented eliminates the risk of mistakes when adding and mixing buffer and electrolyte
  • Free from PVC, latex and phthalates for patient safety
  • No adverse reactions reported using PERFADEX Plus
Easy to use - trouble free connection and replacement:

Easy to use - trouble free connection and replacement:

  • Click port and XVIVO Click Adapter allow tubing to be connected spike-free with one simple click
  • The tubing can rotate on its own axis for improved flexibility
  • Reduces the number of steps you have to take before using
  • Easily removed when changing to a new bag
  • No need for filter
Additional flushing with PERFADEX Plus

Do you flush your donor lungs enough?

Listen to Prof. Niels van der Kaaij talking about how the lungs could benefit from an additional flush of PERFADEX Plus.

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