In the current study, early graft function in 106 recipients of donor lungs preserved using either a low potassium dextran (LPD) solution (i.e. Perfadex; n=51) or Euro-Collins (EC; n=55) solution was assessed. At the time of publication, EC was a commonly used clinical lung preservation solution; however, with its intracellular ion composition, this solution, as well as other high potassium-containing perfusates, were shown to impair pulmonary arterial endothelial cell function. Results demonstrate significant improvements in terms of dynamic lung compliance (p<0.05), length of mechanical ventilation (p=0.006) and 30-day graft survival (p=0.045) in recipients of Perfadex-preserved grafts.
Eur J Cardiothorac Surg / 2001 / doi: 10.1016/s1010-7940(00)00631-x
