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Flush perfusion with low potassium dextran solution improves early graft function in clinical lung transplantation

Martin S, Wilhelmi M, Harringer W, Niedermeyer J, Anssar M, Künsebeck A, Schmitto JD and Haverich A.

In the current study, early graft function in 106 recipients of donor lungs preserved using either a low potassium dextran (LPD) solution (i.e. Perfadex; n=51) or Euro-Collins (EC; n=55) solution was assessed. At the time of publication, EC was a commonly used clinical lung preservation solution; however, with its intracellular ion composition, this solution, as well as other high potassium-containing perfusates, were shown to impair pulmonary arterial endothelial cell function. Results demonstrate significant improvements in terms of dynamic lung compliance (p<0.05), length of mechanical ventilation (p=0.006) and 30-day graft survival (p=0.045) in recipients of Perfadex-preserved grafts.

Eur J Cardiothorac Surg / 2001 / doi: 10.1016/s1010-7940(00)00631-x

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