In this single-center, retrospective cohort study, the effect of end-ischemic DHOPE on extended criteria DBD-grafts (ECD-DBD) was assessed. Inverse probability of treatment weighting (IPTW) was used to overcome selection bias and allow comparison of outcomes in DHOPE-treated grafts (n=121) with grafts preserved by SCS (n=723). The study demonstrated that end-ischemic DHOPE using Liver Assist was associated with a significant reduction of early allograft failure (OR 0.24, p=0.024), fewer severe post-operative complications (Clavien-Dindo grade ≥3; OR 0.57, p=0.046) and lower cumulative morbidity at discharge (CCI: −7.20 points, p=0.003). DHOPE was also associated with improved patient and graft survival (p=0.032; p=0.002). The authors conclude that these findings prompt a wider adoption of this preservation technique in clinical practice, especially when grafts from elderly donors are used.
“/…/ a simple intervention applied at the end of cold preservation improves graft survival and posttransplant course”
Patrono et al, 2022
Am J Transplant / 2022 / doi: 10.1111/ajt.16996
