In this randomized controlled trial (RCT), assessing the effect of end-ischemic DHOPE in DBD liver transplantation, livers donated after brain death were allocated (3:1) to either static cold storage (SCS, n=78) or SCS followed by at least 2 hours of DHOPE using Liver Assist (n=26). While no statistically significant differences in early (up to 90-days) post-operative outcomes were seen following transplantation of low-risk DBD livers, DHOPE in DBD-livers with a donor risk index (DRI) above 1.7 was associated with significantly better early graft function (MEAF score: 4.92 vs 6.31, p=0.037), lower overall morbidity (CCI: 4.35 vs 22.60, p=0.05) and improved patient survival (100% vs 84.6%).
“/…/ HOPE exerts beneficial effects on early LT outcomes from high-risk DBDs.”
Grat et al 2023
Ann Surg / 2023 / doi: 10.1097/SLA.0000000000006055
