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Routine end-ischemic hypotherm...

Routine end-ischemic hypothermic oxygenated machine perfusion in liver transplantation from donors after brain death: A randomized controlled trial.

Grat M, Morawski M, Zhylko A, Rykowski P,Krasnodebski M, Wyporski A, Borkowski J, Lewandowski Z, Kobryn K, Stankiewicz R, Stypulkowski J, Holowko W, Patkowski W, Mielczarek-Puta M, Struga M, Szczepankiewicz B, Gornicka B, Krawczyk M.

In this randomized controlled trial (RCT), assessing the effect of end-ischemic DHOPE in DBD liver transplantation, livers donated after brain death were allocated (3:1) to either static cold storage (SCS, n=78) or SCS followed by at least 2 hours of DHOPE using Liver Assist (n=26). While no statistically significant differences in early (up to 90-days) post-operative outcomes were seen following transplantation of low-risk DBD livers, DHOPE in DBD-livers with a donor risk index (DRI) above 1.7 was associated with significantly better early graft function (MEAF score: 4.92 vs 6.31, p=0.037), lower overall morbidity (CCI: 4.35 vs 22.60, p=0.05) and improved patient survival (100% vs 84.6%).


“/…/ HOPE exerts beneficial effects on early LT outcomes from high-risk DBDs.”

Grat et al 2023

Ann Surg / 2023 / doi: 10.1097/SLA.0000000000006055

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