The United Network for Organ Sharing (UNOS) database was queried from 2015 to 2023 to investigate factors associated with the development of PGD grade 3 (PGD3), and the effect of ex vivo lung perfusion (EVLP). A total of 21.4% of patients were identified as having PGD3 following lung transplant. Those with PGD3 suffered significantly worse perioperative morbidity, mortality, and had worse long-term survival. PGD3 was also independently associated with increased mortality. Matched EVLP PGD3 recipients had significantly higher use of ECMO postoperatively; however, they did not suffer other significant morbidity or mortality as compared to PGD3 recipients without EVLP use. EVLP use prior to transplantation was significantly associated with decreased PGD3 development, while having no significant association with early mortality.
J. Clin. Med. / 2024 / doi: https://doi.org/10.3390/jcm13154440
