Tingle SJ, Figueiredo RS, Moir JAG, Goodfellow M, Talbot D and Wilson CH.
Published in 2019, this Cochrane Review set out to compare hypothermic and normothermic machine perfusion (HMP and NMP) of deceased donor kidneys to standard static cold storage (SCS). While no completed studies on NMP were identified, 16 studies (2266 participants) comparing HMP with SCS were included in the review. Meta-analysis demonstrates that HMP reduces the risk of DGF by 23% (p=0.0006) compared to SCS, and that HMP likely improves graft survival and leads to cost savings in both the US and European settings. The authors conclude that HMP is superior to SCS in deceased donor kidney transplantation, and that this is true for both DBD and DCD kidneys.
Cochrane Database of Systematic Reviews / 2019 / doi: 10.1002/14651858.CD011671.pub2.
