This prospective, first-in-human clinical trial aimed to evaluate the safety and feasibility of extended dual hypothermic oxygenated perfusion (DHOPE) to enable day-time scheduling of transplantation surgeries. Based on the completion time of the donor procedure, 24 livers donated after brain death were assigned to undergo either standard DHOPE for 1-2 hours (n=12) or prolonged DHOPE for ≥4 hours (n=12). With a median machine perfusion time of 9.3 hours (IQR 8.0-10.1), prolonged DHOPE using Liver Assist could safely extend the total graft preservation time for up to 20 hours while maintaining favorable outcomes. All livers showed immediate graft function, there were no cases of non-anastomotic biliary strictures (NAS) in either group, and both graft and patient survival was 100% at 1-year. The authors conclude that DHOPE is both safe and feasible in prolonging the preservation time of donor livers and enables daytime transplantation procedures.
“Prolonged DHOPE can improve logistical efficiency, allowing for the optimal utilization of deceased donor livers while maintaining favorable outcomes”
Brüggenwirth et al 2024
“The ability to safely extend donor liver preservation through DHOPE is poised to revolutionize current liver transplantation practices”
Brüggenwirth et al 2024
“The ability to extend the preservation window to up to 20 h using [DHOPE] has the potential to reshape the landscape of liver transplantation”
Brüggenwirth et al 2024
EClinicalMedicine / 2024 / doi: 10.1016/j.eclinm.2023.102411
