This publication is a report of the first three clinical cases of transplantation of hearts donated after circulatory death (DCD) using direct procurement followed by hypothermic oxygenated perfusion (DP-HOPE).
The donors were Maastricht category III, of ages 40-52 years, and the functional warm ischemic times were 15-21 minutes. All donor hearts perfused on the XVIVO Heart Assist Transport had stable aortic flows during a total out-of-body-time of 4-6 hours. All three recipients were easily weaned off cardiopulmonary bypass in sinus rhythm and were extubated in the operating room. Perioperative transesophageal echocardiography showed good biventricular function without any relevant inotropic support. None of the patients experienced Primary Graft Dysfunction (PGD) and none received mechanical circulatory support. All three patients are at home and in good health at respectively 110, 90, and 55 days posttransplant.
“DP-HOPE is a promising strategy to improve and simplify DCD heart procurement and preservation.”
Brouckaert et al, 2024
J Heart Lung Transplant / 2024 / doi.org/10.1016/j.healun.2024.07.018
The XVIVO Heart Technology is not regulatory approved on any market and its safety and efficacy has not been established.
The XVIVO Heart Technology is not commercially available.
